GNRHR
GNRHR，即促性腺激素释放激素受体，别名GRHR、Gonadotropin-releasing hormone receptor、GnRH receptor、GnRH-R。它是一种G蛋白偶联受体，主要在垂体前叶中表达，参与调节生殖激素的释放。GNRHR的作用机制主要是通过与促性腺激素释放激素（GnRH）结合，激活受体，进而通过G蛋白介导的信号转导，增加细胞内cAMP的水平，促进黄体生成素（LH）和卵泡刺激素（FSH）的释放。GNRHR不仅在生殖系统中发挥关键作用，还与多种疾病的发生发展有关。例如，在乳腺癌中，GNRHR的表达与肿瘤的临床病理特征和预后相关，特别是在激素受体阴性的乳腺癌中，GNRHR的高表达可能与改善的无病生存期（DFS）相关。此外，GNRHR的信号传导在垂体细胞中涉及丝裂原活化蛋白激酶（MAPK）级联的激活，为信号从细胞表面到细胞核的传递提供了重要的联系，并在促性腺激素的转录调节中起作用。GNRHR也在非垂体细胞中表达，并发现其在某些细胞中抑制细胞增殖，因此，GNRHR代表了用于癌症治疗的GnRH类似物的潜在靶标。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA823966(GNRHR Antibody) at dilution 1/117, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA823966(GNRHR Antibody) at dilution 1/117, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 231 cells, mouse testis tissue, Primary antibody: CSB-PA823966(GNRHR Antibody) at dilution 1/2350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 25 seconds
GNRHR Antibodies
GNRHR for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA009637GA01HU | GNRHR Antibody | Human | ELISA,WB,IHC |
| CSB-PA008891 | GNRHR Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA033761 | GNRHR Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA823966 | GNRHR Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
GNRHR Proteins
GNRHR Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637MO1 CSB-EP009637MO1 CSB-BP009637MO1 CSB-MP009637MO1 CSB-EP009637MO1-B |
Recombinant Mouse Gonadotropin-releasing hormone receptor (Gnrhr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637MO | Recombinant Mouse Gonadotropin-releasing hormone receptor (Gnrhr) | in vitro E.coli expression system |
GNRHR Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637RA1 CSB-EP009637RA1 CSB-BP009637RA1 CSB-MP009637RA1 CSB-EP009637RA1-B |
Recombinant Rat Gonadotropin-releasing hormone receptor (Gnrhr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637RA | Recombinant Rat Gonadotropin-releasing hormone receptor (Gnrhr) | in vitro E.coli expression system |
GNRHR Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637SH1 CSB-EP009637SH1 CSB-BP009637SH1 CSB-MP009637SH1 CSB-EP009637SH1-B |
Recombinant Sheep Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637SH | Recombinant Sheep Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637HU1 CSB-EP009637HU1 CSB-BP009637HU1 CSB-MP009637HU1 CSB-EP009637HU1-B |
Recombinant Human Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637HU | Recombinant Human Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637BO1 CSB-EP009637BO1 CSB-BP009637BO1 CSB-MP009637BO1 CSB-EP009637BO1-B |
Recombinant Bovine Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637BO | Recombinant Bovine Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637PI1 CSB-EP009637PI1 CSB-BP009637PI1 CSB-MP009637PI1 CSB-EP009637PI1-B |
Recombinant Pig Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637PI | Recombinant Pig Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637HO1 CSB-EP009637HO1 CSB-BP009637HO1 CSB-MP009637HO1 CSB-EP009637HO1-B |
Recombinant Horse Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637HO | Recombinant Horse Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637GU1 CSB-EP009637GU1 CSB-BP009637GU1 CSB-MP009637GU1 CSB-EP009637GU1-B |
Recombinant Guinea pig Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637GU | Recombinant Guinea pig Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637MOW CSB-EP009637MOW CSB-BP009637MOW CSB-MP009637MOW CSB-EP009637MOW-B |
Recombinant Macaca mulatta Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GNRHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637DO1 CSB-EP009637DO1 CSB-BP009637DO1 CSB-MP009637DO1 CSB-EP009637DO1-B |
Recombinant Dog Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637DO | Recombinant Dog Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Trichosurus vulpecula (Brush-tailed possum)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637TQG1 CSB-EP009637TQG1 CSB-BP009637TQG1 CSB-MP009637TQG1 CSB-EP009637TQG1-B |
Recombinant Trichosurus vulpecula Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637TQG | Recombinant Trichosurus vulpecula Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Bos mutus grunniens (Wild yak) (Bos grunniens)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637BPD1 CSB-EP009637BPD1 CSB-BP009637BPD1 CSB-MP009637BPD1 CSB-EP009637BPD1-B |
Recombinant Bos mutus grunniens Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637BPD | Recombinant Bos mutus grunniens Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
GNRHR Proteins for Octopus vulgaris (Common octopus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009637OAH1 CSB-EP009637OAH1 CSB-BP009637OAH1 CSB-MP009637OAH1 CSB-EP009637OAH1-B |
Recombinant Octopus vulgaris Gonadotropin-releasing hormone receptor (GNRHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF009637OAH | Recombinant Octopus vulgaris Gonadotropin-releasing hormone receptor (GNRHR) | in vitro E.coli expression system |
