GRM2
GRM2，即代谢型谷氨酸受体2，别名GPRC1B、mGlu2、MGLUR2等。它是一种G蛋白偶联受体(GPCR)，主要在神经元和肌肉细胞上表达。GRM2的作用机制是通过与特定的配体结合，激活细胞内的信号转导通路，影响细胞内的生理过程。配体结合导致GRM2发生构象变化，进而触发通过鸟苷酸结合蛋白（G蛋白）的信号传导，并调节下游效应因子，如腺苷酸环化酶的活性。GRM2的信号传导抑制了腺苷酸环化酶活性，可能参与调节神经传导的抑制或与突触形成及突触稳定有关。GRM2在生物学上的意义非常重要，它不仅在神经系统中发挥关键作用，调节突触传递和海马功能，还涉及到多种神经病理状态，包括神经退行性疾病和精神疾病。GRM2的表达在成年海马齿状颗粒细胞中特别高，对成年海马中新生齿状颗粒细胞的发育和功能整合至关重要。此外，GRM2还通过调节MEK/ERK1/2信号通路的磷酸化和激活状态，影响神经元的发育。GRM2的功能异常与多种脑部疾病的发生发展有关，因此，它也是药物开发和神经科学研究的重要靶点。
热销产品
GRM2 Antibody (CSB-PA621775LA01HU)
验证数据
Western Blot
Positive WB detected in: Rat heart tissue
All lanes: GRM2 antibody at 5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 96 kDa
Observed band size: 96 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA621775LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
GRM2 Antibodies
GRM2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA009932GA01HU | GRM2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009020 | GRM2 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA621775LA01HU | GRM2 Antibody | Human, Rat | ELISA, WB, IF |
| CSB-PA621775LC01HU | GRM2 Antibody, FITC conjugated | Human | |
| CSB-PA621775LD01HU | GRM2 Antibody, Biotin conjugated | Human | ELISA |
GRM2 Proteins
GRM2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP009932RA CSB-EP009932RA CSB-BP009932RA CSB-MP009932RA CSB-EP009932RA-B |
Recombinant Rat Metabotropic glutamate receptor 2 (Grm2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP621775HU CSB-EP621775HU CSB-BP621775HU CSB-MP621775HU CSB-EP621775HU-B |
Recombinant Human Metabotropic glutamate receptor 2 (GRM2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP621804MO CSB-EP621804MO CSB-BP621804MO CSB-MP621804MO CSB-EP621804MO-B |
Recombinant Mouse Metabotropic glutamate receptor 2 (Grm2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
