GUCY2C
GUCY2C,即鸟苷酸环化酶2C,别名GC-C、STaR、DIAR6、GUC2C、MECIL、MUCIL等。这是一种在人体中由GUCY2C基因编码的跨膜蛋白,属于受体鸟苷酸环化酶家族。GUCY2C主要在肠上皮细胞中表达,其蛋白结构由细胞外配体结合结构域、跨膜结构域、细胞质结构域、催化区和羧基末端区域组成。GUCY2C的作用机制是通过其配体,如鸟苷素、尿鸟苷素以及热稳定性肠毒素STa的结合,激活GUCY2C,进而催化细胞内第二信使环磷酸鸟苷(cGMP)的产生,这一过程在调节体内平衡、维持肠道屏障功能和发挥抗炎作用中发挥重要作用。GUCY2C的异常表达与多种疾病相关,包括家族性腹泻、胎粪性肠梗阻、结直肠癌等。
热销产品
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) (CSB-MP010053HUd9)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.
GUCY2C Recombinant Monoclonal Antibody (CSB-RA010053A3HU)
验证数据

The Binding Activity of Human GUCY2C with Anti-GUCY2C recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C (CSB-MP010053HU) at 5 μg/mL can bind Anti-GUCY2C recombinant antibody, the EC50 is 5.630-9.996 ng/mL.

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected CT26 cells surface (green line) and transfected Human GUCY2C CT26 stable cells surface (red line) were stained with anti-GUCY2C antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
GUCY2C Antibodies
GUCY2C for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA010053LA01HU | GUCY2C Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA010053LB01HU | GUCY2C Antibody, HRP conjugated | Human | ELISA |
CSB-PA010053LC01HU | GUCY2C Antibody, FITC conjugated | Human | |
CSB-PA010053LD01HU | GUCY2C Antibody, Biotin conjugated | Human | ELISA |
CSB-RA010053A2HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
CSB-RA010053A3HU | GUCY2C Recombinant Monoclonal Antibody | Human | ELISA, FC |
GUCY2C Proteins
GUCY2C Proteins for Cavia porcellus (Guinea pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP010053GU CSB-EP010053GU CSB-BP010053GU CSB-MP010053GU CSB-EP010053GU-B |
Recombinant Guinea pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast |
CSB-EP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | E.coli |
CSB-BP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
CSB-MP010053RA | Recombinant Rat Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |
GUCY2C Proteins for Sus scrofa (Pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP010053PI CSB-EP010053PI CSB-BP010053PI CSB-MP010053PI CSB-EP010053PI-B |
Recombinant Pig Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GUCY2C Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP010053HU CSB-EP010053HU CSB-EP010053HU-B |
Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial | Baculovirus |
CSB-MP010053HU | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
CSB-MP010053HUd9 | Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) | Mammalian cell |
GUCY2C Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP664972MO CSB-EP664972MO CSB-EP664972MO-B |
Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Baculovirus |
CSB-MP664972MO | Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial | Mammalian cell |