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GUCY2C

GUCY2C,即鸟苷酸环化酶2C,别名GC-C、STaR、DIAR6、GUC2C、MECIL、MUCIL等。这是一种在人体中由GUCY2C基因编码的跨膜蛋白,属于受体鸟苷酸环化酶家族。GUCY2C主要在肠上皮细胞中表达,其蛋白结构由细胞外配体结合结构域、跨膜结构域、细胞质结构域、催化区和羧基末端区域组成。GUCY2C的作用机制是通过其配体,如鸟苷素、尿鸟苷素以及热稳定性肠毒素STa的结合,激活GUCY2C,进而催化细胞内第二信使环磷酸鸟苷(cGMP)的产生,这一过程在调节体内平衡、维持肠道屏障功能和发挥抗炎作用中发挥重要作用。GUCY2C的异常表达与多种疾病相关,包括家族性腹泻、胎粪性肠梗阻、结直肠癌等。

热销产品

Recombinant Human Heat-stable enterotoxin receptor (GUCY2C), partial (Active) (CSB-MP010053HUd9)

验证数据

CSB-MP010053HUd9

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP010053HUd9

Activity
Measured by its binding ability in a functional ELISA. Immobilized human GUCY2C at 5 μg/ml can bind Anti-GUCY2C recombinant antibody (CSB-RA010053A2HU), the EC50 is 3.049-4.660 ng/mL.

GUCY2C Recombinant Monoclonal Antibody (CSB-RA010053A3HU)

验证数据

CSB-RA010053A3HU

The Binding Activity of Human GUCY2C with Anti-GUCY2C recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GUCY2C (CSB-MP010053HU) at 5 μg/mL can bind Anti-GUCY2C recombinant antibody, the EC50 is 5.630-9.996 ng/mL.

CSB-RA010053A3HU

T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA010053A3HU

Untransfected CT26 cells surface (green line) and transfected Human GUCY2C CT26 stable cells surface (red line) were stained with anti-GUCY2C antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

GUCY2C Antibodies

GUCY2C for Homo sapiens (Human)

GUCY2C Proteins

GUCY2C Proteins for Cavia porcellus (Guinea pig)

GUCY2C Proteins for Rattus norvegicus (Rat)

GUCY2C Proteins for Sus scrofa (Pig)

GUCY2C Proteins for Homo sapiens (Human)

GUCY2C Proteins for Mus musculus (Mouse)