HSPA5

HSPA5，即热休克蛋白家族A成员5”，别名BiP、GRP78。它是一种分子伴侣蛋白，主要在内质网中发挥作用，由人体细胞自身的基因编码。HSPA5的作用机制涉及帮助蛋白质的正确折叠、组装和运输。当细胞受到各种应激条件，如热休克、氧化应激或营养物质缺乏时，HSPA5的表达会显著增加，以应对蛋白质折叠错误和聚集的问题。HSPA5通过形成复合体与未折叠或错误折叠的蛋白质结合，防止它们聚集，并促进其正确折叠或重折叠。HSPA5在生物学上的意义主要体现在其对细胞应激反应的调控和蛋白质稳态的维持上。作为内质网应激反应的关键分子伴侣，HSPA5参与了未折叠蛋白反应（UPR），在细胞适应和生存中发挥重要作用。HSPA5还与多种细胞过程相关，包括细胞信号传导、细胞周期控制、细胞凋亡以及免疫应答。在肿瘤细胞中，HSPA5的高表达与肿瘤细胞的增殖、侵袭和化疗抗性有关，使其成为癌症治疗中的潜在靶点。此外，HSPA5在神经退行性疾病中也有重要作用，其功能异常可能与疾病的发生发展相关。

热销产品

Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5), partial (CSB-EP010827HU1)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HSPA5 Recombinant Monoclonal Antibody (CSB-RA847116A0HU)

验证数据

IHC image of CSB-RA847116A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

HSPA5 Antibody

HSPA5 Protein

HSPA5 ELISA Kit

HSPA5 Antibodies

HSPA5 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA010827GA01HU	HSPA5 Antibody	Human,Mouse,Rat,Zebrafish	ELISA,WB,IHC
CSB-PA05027A0Rb	HSPA5 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA05027B0Rb	HSPA5 Antibody, HRP conjugated	Human	ELISA
CSB-PA002981	HSPA5 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, IF, ELISA
CSB-PA873500	HSPA5 Antibody	Human,Mouse,Rat	WB,IHC,ELISA
CSB-RA847116A0HU	HSPA5 Recombinant Monoclonal Antibody	Human	ELISA, IHC

HSPA5 for Mus musculus (Mouse)

产品货号	产品名称	种属反应性	应用类型
CSB-PA010827YA01MO	Hspa5 Antibody	Mouse, Rat	ELISA, WB, IF
CSB-PA010827YB01MO	Hspa5 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA010827YC01MO	Hspa5 Antibody, FITC conjugated	Mouse
CSB-PA010827YD01MO	Hspa5 Antibody, Biotin conjugated	Mouse	ELISA

HSPA5 Proteins

HSPA5 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-BP010827HU CSB-MP010827HU CSB-EP010827HU-B	Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010827HU1	Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5), partial	E.coli
CSB-EP010827HU	Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5)	E.coli
CSB-YP010827HU	Recombinant Human Endoplasmic reticulum chaperone BiP (HSPA5)	Yeast

HSPA5 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP010827MO	Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5)	Yeast
CSB-EP010827MO	Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5)	E.coli
CSB-BP010827MO CSB-MP010827MO CSB-EP010827MO-B	Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Equus caballus (Horse)

产品货号	产品名称	来源
CSB-YP010827HO CSB-EP010827HO CSB-BP010827HO CSB-MP010827HO CSB-EP010827HO-B	Recombinant Horse 78 kDa glucose-regulated protein (HSPA5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Sus scrofa (Pig)

产品货号	产品名称	来源
CSB-YP010827PI CSB-EP010827PI CSB-BP010827PI CSB-MP010827PI CSB-EP010827PI-B	Recombinant Pig 78 kDa glucose-regulated protein (HSPA5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP010827RA CSB-EP010827RA CSB-BP010827RA CSB-MP010827RA CSB-EP010827RA-B	Recombinant Rat 78 kDa glucose-regulated protein (Hspa5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Mesocricetus auratus (Golden hamster)

产品货号	产品名称	来源
CSB-YP010827MRG CSB-EP010827MRG CSB-BP010827MRG CSB-MP010827MRG CSB-EP010827MRG-B	Recombinant Mesocricetus auratus Endoplasmic reticulum chaperone BiP (HSPA5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP604380BO CSB-EP604380BO CSB-BP604380BO CSB-MP604380BO CSB-EP604380BO-B	Recombinant Bovine 78 kDa glucose-regulated protein (HSPA5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus)

产品货号	产品名称	来源
CSB-YP662144FKA CSB-EP662144FKA CSB-BP662144FKA CSB-MP662144FKA CSB-EP662144FKA-B	Recombinant Spermophilus tridecemlineatus 78 kDa glucose-regulated protein (HSPA5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Pongo abelii (Sumatran orangutan)

产品货号	产品名称	来源
CSB-YP728890PYX CSB-EP728890PYX CSB-BP728890PYX CSB-MP728890PYX CSB-EP728890PYX-B	Recombinant Pongo abelii 78 kDa glucose-regulated protein (HSPA5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP835454CH CSB-EP835454CH CSB-BP835454CH CSB-MP835454CH CSB-EP835454CH-B	Recombinant Chicken 78 kDa glucose-regulated protein (HSPA5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HSPA5 Proteins for Xenopus laevis (African clawed frog)

产品货号	产品名称	来源
CSB-YP852733XBE CSB-EP852733XBE CSB-BP852733XBE CSB-MP852733XBE CSB-EP852733XBE-B	Recombinant Xenopus laevis Endoplasmic reticulum chaperone BiP (hspa5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli