IL18
IL18，即白介素18，它是一种在人体中由IL18基因编码的细胞因子，属于IL-1家族成员。IL18在多种细胞类型中表达，包括T细胞、NK细胞、树突状细胞等。其作用机制涉及到与IL18受体结合，该受体由α链和β链组成，其中α链负责配体结合，β链介导信号传导。IL18通过与其受体结合，激活下游的信号传导途径，如通过JAK/STAT通路，进而影响细胞的增殖、分化和效应功能。IL18在生物学上的意义主要体现在其作为免疫调节因子参与炎症和免疫应答过程。它能诱导T细胞产生干扰素-γ（IFN-γ），促进NK细胞和其他免疫细胞的活化，以及刺激细胞因子如肿瘤坏死因子-α（TNF-α）、IL-1β等的产生。IL18在促进Th1型免疫应答中发挥重要作用，并与多种炎症性疾病、肿瘤和自身免疫性疾病的发生发展密切相关。例如，IL18的表达水平在某些自身免疫疾病中升高，可能作为疾病活动性的标志。此外，IL18的成熟过程涉及非经典炎症小体途径，其中caspase-4/5的活化可以切割前体IL18，释放其成熟形式以发挥生物学功能。
热销产品
Recombinant Human Interleukin-18 (IL18) (CSB-EP614514HUd7)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IL18 Antibody (CSB-PA614514YA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA614514YA01HU at dilution of 1:20
Human Interleukin 18,IL-18 ELISA KIT (CSB-E07450h)
验证数据
货号：CSB-E07450h
规格：96T/48T
灵敏度：7.8 pg/mL
检测范围：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL18 Antibodies
IL18 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011608GA01HU | IL18 Antibody | Human, Rat | ELISA,WB,IHC,IF |
| CSB-PA614514YA01HU | IL18 Antibody | Human | ELISA, IHC |
| CSB-PA614514YD01HU | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA614514YC01HU | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA614514YB01HU | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377A0Rb | IL18 Antibody | Human | ELISA |
| CSB-PA08377B0Rb | IL18 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08377C0Rb | IL18 Antibody, FITC conjugated | Human | |
| CSB-PA08377D0Rb | IL18 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA081015 | IL18 Antibody | Human | ELISA,WB,IHC |
| CSB-PA634259 | IL18 Antibody | Human | ELISA,WB,IHC |
| CSB-RA614514MA1HU | IL18 Recombinant Monoclonal Antibody | Human | ELISA, FC |
IL18 for Dog
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA895937LA01DO | IL18 Antibody | Dog | ELISA |
IL18 Proteins
IL18 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011608MO | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MO | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
| CSB-BP011608MO CSB-MP011608MO CSB-EP011608MO-B |
Recombinant Mouse Interleukin-18 (Il18) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-YP011608MOb0 | Recombinant Mouse Interleukin-18 (Il18) | Yeast |
| CSB-EP011608MOe1 | Recombinant Mouse Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011608RA CSB-EP011608RA CSB-BP011608RA CSB-MP011608RA CSB-EP011608RA-B |
Recombinant Rat Interleukin-18 (Il18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP176194r | Recombinant Rat Interleukin-18 (Il18) | E.coli |
IL18 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011608PI CSB-EP011608PI CSB-BP011608PI CSB-MP011608PI CSB-EP011608PI-B |
Recombinant Pig Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP614514HU | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU CSB-BP614514HU CSB-MP614514HU CSB-EP614514HU-B |
Recombinant Human Interleukin-18 (IL18) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | Yeast |
| CSB-EP614514HU(A4) | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUd7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-EP614514HUc7 | Recombinant Human Interleukin-18 (IL18) | E.coli |
| CSB-MP614514HU-WD | Recombinant Human Interleukin-18 (IL18) (Active) | Mammalian cell |
IL18 Proteins for Capra hircus (Goat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP672507GO CSB-EP672507GO CSB-BP672507GO CSB-MP672507GO CSB-EP672507GO-B |
Recombinant Goat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Boselaphus tragocamelus (Nilgai)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP689269BUN CSB-EP689269BUN CSB-BP689269BUN CSB-MP689269BUN CSB-EP689269BUN-B |
Recombinant Boselaphus tragocamelus Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP819130CH CSB-EP819130CH CSB-BP819130CH CSB-MP819130CH CSB-EP819130CH-B |
Recombinant Chicken Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP850184CA CSB-EP850184CA CSB-BP850184CA CSB-MP850184CA CSB-EP850184CA-B |
Recombinant Cat Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP866143BO CSB-EP866143BO CSB-BP866143BO CSB-MP866143BO CSB-EP866143BO-B |
Recombinant Bovine Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Equus caballus (Horse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP895012HO CSB-EP895012HO CSB-BP895012HO CSB-MP895012HO CSB-EP895012HO-B |
Recombinant Horse Interleukin-18 (IL18) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP895937DO CSB-BP895937DO CSB-MP895937DO CSB-EP895937DO-B |
Recombinant Dog Interleukin-18 (IL18) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL18 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP895937DO | Recombinant Dog Interleukin-18 (IL18) | E.coli |
IL18 ELISA Kit
IL18 ELISA Kit for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL011608BO | Bovine Interleukin-18(IL18) ELISA kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E10070Ch | Chicken Interleukin 18,IL-18 ELISA KIT | serum, plasma, tissue Homogenates | 1.95 pg/mL |
IL18 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E09848c | Dog Interleukin 18,IL-18 ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 3.12 pg/mL |
IL18 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E07450h | Human Interleukin 18,IL-18 ELISA KIT | serum, plasma, urine, tissue homogenates | 7.8 pg/mL |
IL18 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04609m | Mouse Interleukin 18,IL-18 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.39 pg/mL |
IL18 ELISA Kit for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E06781p | Pig Interleukin 18,IL-18 ELISA Kit | serum, plasma, tissue homogenates | 7.81 pg/mL |
IL18 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04610r | Rat Interleukin 18,IL-18 Elisa Kit | serum, plasma, cell culture supernates | 0.039 ng/mL |
