IL23R
IL23R，即白细胞介素23受体，别名 IL 23R、IL-23 receptor、IL-23R、IL23 Receptor、Il23r。它是一种由IL23R基因编码的蛋白质，属于I型细胞因子受体家族成员，主要在免疫系统的细胞如T细胞和NK细胞中表达。IL23R的作用机制涉及与其配体IL-23结合，进而激活JAK2/STAT3信号通路，促进Th17细胞的分化和激活，参与调节免疫应答和炎症反应。IL23R参与了多种免疫细胞的激活和调节过程，尤其是与Th17细胞的分化和自身免疫性疾病的发生发展密切相关。IL23R的功能异常与多种疾病有关，包括炎症性肠病、克罗恩病、银屑病、强直性脊柱炎和溃疡性结肠炎等。因此，IL23R是免疫学研究和相关疾病治疗中的一个潜在靶点。研究表明，IL-23介导的信号传导在炎症性肠病、克罗恩病和溃疡性结肠炎的病理学中起着重要作用，同时，IL-23驱动的Th17细胞在炎症中也起着关键作用。
热销产品
Recombinant Human Interleukin-23 receptor (IL23R), partial (Active) (CSB-AP004371HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human rectal cancer tissue using CSB-PA273292(IL23R Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human sigmoid tissue, Primary antibody: CSB-PA273292(IL23R Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
IL23R Antibodies
IL23R for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011639KA01HU | IL23R Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA929770 | IL23R Antibody | Human | ELISA,IHC |
| CSB-PA273292 | IL23R Antibody | Human | ELISA,WB,IHC |
| CSB-PA733162LA01HU | IL23R Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA733162LB01HU | IL23R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA733162LC01HU | IL23R Antibody, FITC conjugated | Human | |
| CSB-PA733162LD01HU | IL23R Antibody, Biotin conjugated | Human | ELISA |
IL23R Proteins
IL23R Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP733162HU CSB-EP733162HU CSB-BP733162HU CSB-MP733162HU CSB-EP733162HU-B |
Recombinant Human Interleukin-23 receptor (IL23R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP004371HU | Recombinant Human Interleukin-23 receptor (IL23R), partial (Active) | Mammalian cell |
IL23R Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP814324MO CSB-EP814324MO CSB-BP814324MO CSB-MP814324MO CSB-EP814324MO-B |
Recombinant Mouse Interleukin-23 receptor (Il23r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
