IL3RA
IL3RA，即白细胞介素3受体亚单位α，别名CD123。它主要来源于骨髓中的造血干细胞，特别是在活化的T细胞和NK细胞中表达较高。IL3RA的作用机制是通过与IL-3结合，进而与IL-3受体β链（CD131）结合，形成高亲和力的受体复合体，激活与受体相关的Janus激酶（JAKs），尤其是JAK2，进而激活信号转导和激活转录因子（STAT5），引发细胞内信号传导。IL3RA对多种造血细胞的增殖和分化的调控作用，包括粒细胞、单核细胞、巨噬细胞、嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞等。IL3RA在多种血液系统恶性肿瘤中表达，也是免疫治疗和靶向治疗的潜在靶点。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA925610(IL3RA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA925610(IL3RA Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
IL3RA Antibodies
IL3RA for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011658GA01HU | IL3RA Antibody | Human | ELISA,WB |
| CSB-PA006148 | IL3RA Antibody | Human | WB, ELISA |
| CSB-PA925610 | IL3RA Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA911335 | IL3RA Antibody | Human | ELISA,IHC |
IL3RA Proteins
IL3RA Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011658MO1 CSB-EP011658MO1 CSB-BP011658MO1 CSB-MP011658MO1 CSB-EP011658MO1-B |
Recombinant Mouse Interleukin-3 receptor subunit alpha (Il3ra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011658MO | Recombinant Mouse Interleukin-3 receptor subunit alpha (Il3ra) | in vitro E.coli expression system |
IL3RA Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011658HU1 CSB-EP011658HU1 CSB-BP011658HU1 CSB-MP011658HU1 CSB-EP011658HU1-B |
Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011658HU | Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA) | in vitro E.coli expression system |
