ITGB2
ITGB2全称为整合素β2亚基，也被称为CD18或淋巴细胞功能相关抗原-1（LFA-1）组成部分。该蛋白主要与α亚基结合形成异源二聚体，在免疫细胞表面广泛表达，参与白细胞迁移、炎症反应和免疫应答。ITGB2功能异常会导致白细胞黏附缺陷症（LAD），患者因免疫细胞无法有效迁移至感染部位，常出现反复细菌感染、伤口愈合困难等症状。ITGB2与慢性炎症性疾病、动脉粥样硬化及肿瘤转移也存在关联。
在药物研发领域，针对ITGB2的靶向策略多聚焦于调控免疫反应。例如LFA-1抑制剂如利妥昔单抗已用于治疗类风湿性关节炎，通过阻断免疫细胞过度活化减轻炎症损伤。新型小分子抑制剂如BMS-986020正在进行临床试验，探索在器官移植排异反应中的应用。部分研究尝试利用纳米抗体技术开发特异性阻断剂，但尚未进入临床阶段。由于整合素家族成员的功能交叉性，如何实现精准靶向仍是当前研究的难点。
热销产品
ITGB2 Antibody (CSB-PA011884LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA011884LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA011884LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ITGB2 Antibodies
ITGB2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005838 | ITGB2 Antibody | Human | ELISA |
| CSB-PA011268 | Phospho-ITGB2 (T758) Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA011269 | ITGB2 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA066585 | ITGB2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA877324 | ITGB2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA011884LA01HU | ITGB2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011884LB01HU | ITGB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011884LC01HU | ITGB2 Antibody, FITC conjugated | Human | |
| CSB-PA011884LD01HU | ITGB2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011884MA1HU | ITGB2 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ITGB2 Proteins
ITGB2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011884MO1 CSB-EP011884MO1 CSB-BP011884MO1 CSB-MP011884MO1 CSB-EP011884MO1-B |
Recombinant Mouse Integrin beta-2 (Itgb2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011884MO | Recombinant Mouse Integrin beta-2 (Itgb2) | in vitro E.coli expression system |
ITGB2 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011884BO1 CSB-EP011884BO1 CSB-BP011884BO1 CSB-MP011884BO1 CSB-EP011884BO1-B |
Recombinant Bovine Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011884BO | Recombinant Bovine Integrin beta-2 (ITGB2) | in vitro E.coli expression system |
ITGB2 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011884PI1 CSB-EP011884PI1 CSB-BP011884PI1 CSB-MP011884PI1 CSB-EP011884PI1-B |
Recombinant Pig Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011884PI | Recombinant Pig Integrin beta-2 (ITGB2) | in vitro E.coli expression system |
ITGB2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011884HU1 CSB-EP011884HU1 CSB-BP011884HU1 CSB-MP011884HU1 CSB-EP011884HU1-B |
Recombinant Human Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011884HU | Recombinant Human Integrin beta-2 (ITGB2) | in vitro E.coli expression system |
ITGB2 Proteins for Ovis canadensis (Bighorn sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP651222OAAI CSB-EP651222OAAI CSB-BP651222OAAI CSB-MP651222OAAI CSB-EP651222OAAI-B |
Recombinant Ovis canadensis Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB2 Proteins for Capra hircus (Goat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP713335GO CSB-EP713335GO CSB-BP713335GO CSB-MP713335GO CSB-EP713335GO-B |
Recombinant Goat Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB2 Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP728580SH CSB-EP728580SH CSB-BP728580SH CSB-MP728580SH CSB-EP728580SH-B |
Recombinant Sheep Integrin beta-2 (ITGB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB2 ELISA Kit
ITGB2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E10004h | Human integrin β2,ITG β2/CD11+CD18 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
