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JAK2

JAK2,即Janus激酶2,别名Janus kinase 2 、JTK10、THCYT3。它是一种细胞质中的非受体型酪氨酸蛋白激酶,广泛分布于体细胞的胞质中,参与造血和免疫系统等的信号转导,对红细胞的生成及免疫细胞的活化也有重要作用。JAK2的作用机制主要是通过与多种细胞因子受体相关联,当细胞因子与其受体结合后,JAK2被激活并触发下游的JAK-STAT信号通路,参与细胞的增殖、分化、凋亡及免疫调节等众多生物学过程。JAK2的异常激活与多种血液系统恶性肿瘤的发生发展有关,尤其是与骨髓增殖性肿瘤(myeloproliferative neoplasms, MPNs)密切相关,JAK2激酶的突变,如假激酶区V617F的位点突变,是诱发MPNs的重要原因。AK2是治疗MPNs的重要靶标,通过抑制JAK2-STAT信号通路的异常激活来治疗MPNs已成为热门研究方向。

热销产品

Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial (CSB-EP011931HU)

验证数据

CSB-EP011931HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP011931HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.

CSB-EP011931HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.

JAK2 Recombinant Monoclonal Antibody (CSB-RA267127A0HU)

验证数据

CSB-RA267127A0HU

Immunofluorescence staining of Hela Cells with CSB-RA267127A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

JAK2 Antibodies

JAK2 for Homo sapiens (Human)

JAK2 Proteins

JAK2 Proteins for Sus scrofa (Pig)

JAK2 Proteins for Homo sapiens (Human)

JAK2 Proteins for Pongo abelii (Sumatran orangutan)

JAK2 Proteins for Rattus norvegicus (Rat)

JAK2 Proteins for Mus musculus (Mouse)

JAK2 Proteins for Gallus gallus (Chicken)