JAK2
JAK2,即Janus激酶2,别名Janus kinase 2 、JTK10、THCYT3。它是一种细胞质中的非受体型酪氨酸蛋白激酶,广泛分布于体细胞的胞质中,参与造血和免疫系统等的信号转导,对红细胞的生成及免疫细胞的活化也有重要作用。JAK2的作用机制主要是通过与多种细胞因子受体相关联,当细胞因子与其受体结合后,JAK2被激活并触发下游的JAK-STAT信号通路,参与细胞的增殖、分化、凋亡及免疫调节等众多生物学过程。JAK2的异常激活与多种血液系统恶性肿瘤的发生发展有关,尤其是与骨髓增殖性肿瘤(myeloproliferative neoplasms, MPNs)密切相关,JAK2激酶的突变,如假激酶区V617F的位点突变,是诱发MPNs的重要原因。AK2是治疗MPNs的重要靶标,通过抑制JAK2-STAT信号通路的异常激活来治疗MPNs已成为热门研究方向。
热销产品
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial (CSB-EP011931HU)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.
JAK2 Recombinant Monoclonal Antibody (CSB-RA267127A0HU)
验证数据

Immunofluorescence staining of Hela Cells with CSB-RA267127A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
JAK2 Antibodies
JAK2 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA011931LA01HU | JAK2 Antibody | Human | ELISA |
CSB-PA951532 | Phospho-JAK2 (Tyr1007) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA202109 | JAK2 (Ab-1007) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA264562 | JAK2 (Ab-570) Antibody | Human,Rat | ELISA,IHC |
CSB-PA173118 | Phospho-JAK2 (Tyr221) Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA227783 | Phospho-JAK2 (Tyr931) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA212456 | Phospho-JAK2 (Tyr570) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA281490 | JAK2 (Ab-570) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA000562 | Phospho-JAK2 (Y1007) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA003078 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA003079 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA011286 | Phospho-JAK2 (Y570) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011287 | Phospho-JAK2 (Y221) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011288 | Phospho-JAK2 (Y931) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA011289 | Phospho-JAK2 (Y119) Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA011290 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA011291 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA164401 | JAK2 Antibody | Human,Rat | ELISA,IHC |
CSB-PA435870 | JAK2 Antibody | Human,Rat | ELISA,IHC |
CSB-PA406975 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-MA181103 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-MA780030 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA011931A100phHU | Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
CSB-RA267127A0HU | JAK2 Recombinant Monoclonal Antibody | Human | ELISA, IF |
JAK2 Proteins
JAK2 Proteins for Sus scrofa (Pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP011931PI CSB-EP011931PI CSB-BP011931PI CSB-MP011931PI CSB-EP011931PI-B |
Recombinant Pig Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP011931HU CSB-BP011931HU CSB-MP011931HU CSB-EP011931HU-B |
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011931HU | Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | E.coli |
JAK2 Proteins for Pongo abelii (Sumatran orangutan)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP716150PYX CSB-EP716150PYX CSB-BP716150PYX CSB-MP716150PYX CSB-EP716150PYX-B |
Recombinant Pongo abelii Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP717274RA CSB-EP717274RA CSB-BP717274RA CSB-MP717274RA CSB-EP717274RA-B |
Recombinant Rat Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP726782MO CSB-EP726782MO CSB-BP726782MO CSB-MP726782MO CSB-EP726782MO-B |
Recombinant Mouse Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Gallus gallus (Chicken)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP745061CH CSB-EP745061CH CSB-BP745061CH CSB-MP745061CH CSB-EP745061CH-B |
Recombinant Chicken Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |