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KAT2A

KAT2A,即赖氨酸乙酰转移酶2A,别名GCN5、hGCN5、GCN5L2、PCAF-b等。这是一种在人类细胞中广泛表达的组蛋白乙酰转移酶(HAT),主要作用是作为转录激活剂,通过乙酰化组蛋白促进基因的转录激活。KAT2A还具有其他功能,例如通过促进NF-kappa-B亚基RELA的泛素化来充当NF-kappa-B的阻遏物。此外,KAT2A还参与了多种生物学过程,包括长期记忆、大分子代谢过程的正向调控、调节性T细胞分化等。KAT2A的异常表达与多种疾病相关,如癌症、代谢性疾病等,是药物开发的重要靶点之一。

热销产品

KAT2A Antibody (CSB-PA002657)

验证数据

CSB-PA002657

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA002657

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-PA002657

Immunofluorescence staining of Hela cell with CSB-PA002657 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

KAT2A Antibodies

KAT2A for Homo sapiens (Human)

KAT2A Proteins

KAT2A Proteins for Homo sapiens (Human)

KAT2A Proteins for Mus musculus (Mouse)