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KEAP1

KEAP1,即Kelch样ECH相关蛋白1,别名IKBKE抑制因子、Kelch-like protein 19等。它是一种由KEAP1基因编码的蛋白质,主要在细胞质中发挥作用。KEAP1的作用机制主要是通过与NRF2蛋白相互作用,促进NRF2的泛素化和蛋白酶体降解,从而抑制NRF2介导的抗氧化应激和代谢调控基因的表达。KEAP1的功能异常与多种疾病有关,尤其是癌症,其中KEAP1的突变或异常表达可能导致NRF2信号通路的异常激活,进而影响肿瘤细胞的代谢和生存。因此,KEAP1-NRF2信号通路是癌症治疗中的一个潜在靶点。

热销产品

Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1) (CSB-EP012147HU)

验证数据

CSB-EP012147HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KEAP1 Antibody (CSB-PA012147LA01HU)

验证数据

CSB-PA012147LA01HU

Western blot
All lanes: KEAP1 antibody at 2µg/ml
Lane 1: Mouse kidney tissue
Lane 2: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

CSB-PA012147LA01HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012147LA01HU at dilution of 1:100

Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit (CSB-EL012147HU)

验证数据

CSB-EL012147HU 标准曲线

货号:CSB-EL012147HU

规格:96T/48T

灵敏度:6.25 pg/mL

检测范围:25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KEAP1 Antibodies

KEAP1 for Homo sapiens (Human)

KEAP1 for Mus musculus (Mouse)

KEAP1 Proteins

KEAP1 Proteins for Rattus norvegicus (Rat)

KEAP1 Proteins for Sus scrofa (Pig)

KEAP1 Proteins for Pongo abelii (Sumatran orangutan)

KEAP1 Proteins for Mus musculus (Mouse)

KEAP1 Proteins for Homo sapiens (Human)

KEAP1 ELISA Kit

KEAP1 ELISA Kit for Homo sapiens (Human)

KEAP1 ELISA Kit for Mus musculus (Mouse)