KIR2DL1
KIR2DL1是杀伤细胞免疫球蛋白样受体家族的重要成员,全称为杀伤细胞免疫球蛋白样受体2DL1,也被称作CD158a。KIR2DL1主要表达于自然杀伤细胞(NK细胞)表面,通过识别特定的人类白细胞抗原(HLA-C2亚型),向NK细胞传递抑制性信号,维持机体对健康细胞的免疫耐受。当靶细胞表面HLA-I类分子表达异常时,KIR2DL1的抑制作用减弱,NK细胞可被激活并杀伤靶细胞,这一机制在抗病毒感染和肿瘤免疫监视中起关键作用。KIR2DL1基因多态性与白血病、艾滋病病程进展及妊娠期子痫前期等疾病密切相关。针对该受体的免疫疗法成为研究热点,例如通过单克隆抗体阻断KIR2DL1与其配体结合,解除NK细胞活性抑制,已在多发性骨髓瘤和急性髓系白血病的临床试验中显示出治疗潜力。部分药物如IPH2101已完成II期试验,为肿瘤免疫治疗提供了新策略。
热销产品
KIR2DL1 Recombinant Monoclonal Antibody (CSB-RA012352MA1HU)
验证数据

IHC image of CSB-RA012352MA1HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
KIR2DL1 Antibodies
KIR2DL1 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA006278 | KIR2DL1 Antibody | Human | WB, ELISA |
CSB-PA012352LA01HU | KIR2DL1 Antibody | Human | ELISA, IHC, IF |
CSB-PA012352LB01HU | KIR2DL1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA012352LC01HU | KIR2DL1 Antibody, FITC conjugated | Human | |
CSB-PA012352LD01HU | KIR2DL1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA012352MA1HU | KIR2DL1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
KIR2DL1 Proteins
KIR2DL1 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP012352HU1 CSB-EP012352HU1 CSB-BP012352HU1 CSB-MP012352HU1 CSB-EP012352HU1-B |
Recombinant Human Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF012352HU | Recombinant Human Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) | in vitro E.coli expression system |