MIA
黑色素瘤抑制性活性蛋白（Melanoma inhibitory activity，MIA）又称MIA1或CD-RAP，最初在黑色素瘤细胞中发现，属于分泌型胞外基质蛋白家族。MIA通过结合细胞表面整合素受体（如α4β1、α5β1）干扰细胞与基质的黏附，同时激活ERK/MAPK信号通路，促进肿瘤细胞侵袭转移。MIA在黑色素瘤、乳腺癌、肝癌等多种恶性肿瘤中高表达，其水平与肿瘤分期、转移风险正相关，可作为预后标志物。近年来，针对MIA的靶向治疗策略逐渐兴起，德国团队开发的MIA抗体已进入临床前研究，能有效抑制黑色素瘤细胞迁移。小分子抑制剂如PD98059通过阻断MIA下游信号通路显示出抗肿瘤潜力。非癌性疾病中，MIA还参与软骨发育调控，其基因突变与骨骼发育异常相关。
热销产品
MIA Antibody (CSB-PA613694LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA613694LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA613694LA01HU at dilution of 1:100
MIA Antibodies
MIA for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA759156 | MIA Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA060224 | MIA Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA283943 | MIA Antibody | Human | IHC,ELISA |
| CSB-PA613694LA01HU | MIA Antibody | Human | ELISA, IHC |
| CSB-PA613694LB01HU | MIA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA613694LC01HU | MIA Antibody, FITC conjugated | Human |
MIA Proteins
MIA Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP613694HU CSB-EP613694HU CSB-BP613694HU CSB-MP613694HU CSB-EP613694HU-B |
Recombinant Human Melanoma-derived growth regulatory protein (MIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP000431HU | Recombinant Human Melanoma-derived growth regulatory protein (MIA) | E.Coli |
MIA Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP631694BO CSB-EP631694BO CSB-BP631694BO CSB-MP631694BO CSB-EP631694BO-B |
Recombinant Bovine Melanoma-derived growth regulatory protein (MIA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP720265MO CSB-EP720265MO CSB-BP720265MO CSB-MP720265MO CSB-EP720265MO-B |
Recombinant Mouse Melanoma-derived growth regulatory protein (Mia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP737099RA CSB-EP737099RA CSB-BP737099RA CSB-MP737099RA CSB-EP737099RA-B |
Recombinant Rat Melanoma-derived growth regulatory protein (Mia) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MIA ELISA Kit
MIA ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL013798MO | Mouse Melanoma-derived growth regulatory protein(MIA) ELISA kit | serum, plasma, tissue homogenates | 1.17 pg/mL |
