MRAS
MRAS全称为肌肉RAS癌基因同源物（Muscle RAS oncogene homolog），属于RAS超家族成员，也被称为RAS样蛋白12（RASL12）。这类蛋白作为细胞内信号转导的"分子开关"，通过结合GTP或GDP状态调控下游通路，尤其在胚胎发育、细胞周期调控中扮演关键角色。MRAS异常激活与多种实体瘤密切相关，例如非小细胞肺癌中检测到该基因的特异性突变位点，可能通过干扰细胞分化程序促进肿瘤进展。MRAS在心脏肥大反应和神经发育障碍中也显示出调控作用，其表达异常与努南综合征等遗传性疾病存在关联。
针对MRAS靶点的药物开发长期受限于其蛋白结构的特殊性，传统小分子抑制剂难以有效结合。但随着KRAS G12C变构抑制剂的成功，研究者开始探索针对MRAS特有突变（如G23V）的共价结合策略。目前已有数款候选化合物进入临床前研究阶段，通过模拟天然蛋白构象或阻断效应蛋白结合域来干预信号传导。MRAS与SHOC2-PP1C复合物的特异性相互作用为开发精准疗法提供了新方向，相关研究成果已进入转化医学验证阶段。
热销产品
Recombinant Human Ras-related protein M-Ras (MRAS) (CSB-EP014781HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MRAS Recombinant Monoclonal Antibody (CSB-RA158563A0HU)
验证数据
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
All lanes: MRAS antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 24, 16 kDa
Observed band size: 24 kDa
MRAS Antibodies
MRAS for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA014781GA01HU | MRAS Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA014781ESR1HU | MRAS Antibody | Human, Mouse | ELISA, WB |
| CSB-PA014781ESR2HU | MRAS Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA014781LA01HU | MRAS Antibody | Human | ELISA, IF |
| CSB-PA014781LD01HU | MRAS Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA014781LC01HU | MRAS Antibody, FITC conjugated | Human | |
| CSB-RA158563A0HU | MRAS Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA014781MA1HU | MRAS Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
MRAS Proteins
MRAS Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP014781RA CSB-EP014781RA CSB-BP014781RA CSB-MP014781RA CSB-EP014781RA-B |
Recombinant Rat Ras-related protein M-Ras (Mras) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MRAS Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP014781MO CSB-EP014781MO CSB-BP014781MO CSB-MP014781MO CSB-EP014781MO-B |
Recombinant Mouse Ras-related protein M-Ras (Mras) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MRAS Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP014781HU CSB-BP014781HU CSB-MP014781HU CSB-EP014781HU-B |
Recombinant Human Ras-related protein M-Ras (MRAS) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP014781HU | Recombinant Human Ras-related protein M-Ras (MRAS) | E.coli |
