MT1A
金属硫蛋白1A(Metallothionein 1A,简称MT1A)是一类广泛存在于人体组织的小分子蛋白,因其富含半胱氨酸残基也被称作"金属结合卫士"。MT1A通过螯合锌、铜等必需金属离子,维持细胞内环境稳定,同时能高效中和重金属毒性物质如镉和汞,在肝脏解毒过程中发挥核心作用。其抗氧化特性对抵御自由基损伤、延缓细胞衰老具有重要价值。
MT1A表达异常与多种病理状态相关。在阿尔茨海默病、帕金森病等神经退行性疾病中,患者脑部MT1A水平显著下降,提示其可能参与神经保护过程。肝癌、乳腺癌等恶性肿瘤组织常出现该蛋白的异常高表达,可能与肿瘤细胞抵抗化疗药物及适应缺氧微环境有关。近年针对MT1A的调控策略逐渐受到关注,包括利用其作为重金属中毒的生物标志物,开发基于金属硫蛋白结构的仿生解毒剂,以及探索通过表观遗传手段调节其表达来增强抗癌疗效。天然产物如姜黄素已被证实可诱导MT1A生成,为抗氧化治疗提供了新思路。
热销产品
Recombinant Human Metallothionein-1A (MT1A), partial (CSB-EP015107HU1)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MT1A Antibody (CSB-PA17444A0Rb)
验证数据

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA17444A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA17444A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA17444A0Rb at dilution of 1:100
Human Metallothionein,MT ELISA Kit (CSB-E09060h)
验证数据

货号:CSB-E09060h
规格:96T/48T
灵敏度:0.813 pg/mL
检测范围:6.25 pg/mL-400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MT1A Antibodies
MT1A for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA17444C0Rb | MT1A Antibody, FITC conjugated | Human | |
CSB-PA17444A0Rb | MT1A Antibody | Human | ELISA, IHC |
MT1A Proteins
MT1A Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP015107HU CSB-EP015107HU CSB-BP015107HU CSB-MP015107HU CSB-EP015107HU-B |
Recombinant Human Metallothionein-1A (MT1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP015107HU1 | Recombinant Human Metallothionein-1A (MT1A), partial | E.coli |
MT1A ELISA Kit
MT1A ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E09060h | Human Metallothionein,MT ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates, urine, saliva | 0.813 pg/mL |