NTRK2

NTRK2全称为神经营养酪氨酸激酶受体2型（Neurotrophic Tyrosine Kinase Receptor Type 2），常简称为TrkB或GP145-TrkB。NTRK2是脑源性神经营养因子（BDNF）的主要受体，通过与配体结合激活下游信号网络，调控神经元存活、突触可塑性和神经递质释放，对学习记忆、情绪调节等脑功能至关重要。NTRK2信号异常与阿尔茨海默病、抑郁症、癫痫等神经系统疾病密切相关，其过度激活也可能导致神经母细胞瘤、肺癌等实体瘤的发生。近年来针对NTRK基因家族融合突变的靶向治疗取得突破，拉罗替尼（Larotrectinib）和恩曲替尼（Entrectinib）等泛TRK抑制剂已获批用于NTRK融合阳性的实体瘤患者，但部分患者用药后出现的激酶区耐药突变仍是临床挑战。目前第二代TRK抑制剂如Selitrectinib正在研发中，旨在克服获得性耐药问题。

热销产品

NTRK2 Recombinant Monoclonal Antibody (CSB-RA619082MA1HU)

验证数据

Immunofluorescence staining of SH-SY5Y cell with CSB-RA619082MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).