PDX1
PDX1，即胰十二指肠同源异形盒1，别名insulinpromoterfactor1、IPF1。它是一种同源盒转录因子，由人类第5号染色体上的PDX1基因编码。PDX1在胰腺发育及β细胞功能维持中起重要调控作用。其作用机制包括结合到胰岛素基因的启动子上，单独或协同其他因子调节胰岛素的合成。PDX1对胰腺发育、β细胞成熟与分化、胰岛素合成与分泌具有关键作用。PDX1基因的缺失或突变可导致胰腺发育不全和糖尿病的发生。PDX1在糖尿病治疗中的研究具有重要的应用前景和潜在价值。
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验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA068736(PDX1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, Jurkat cells, Primary antibody: CSB-PA068736(PDX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
PDX1 Antibodies
PDX1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA017746GA01HU | PDX1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA011230 | PDX1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA068736 | PDX1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA114989 | PDX1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
PDX1 Proteins
PDX1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017746HU CSB-EP017746HU CSB-BP017746HU CSB-MP017746HU CSB-EP017746HU-B |
Recombinant Human Pancreas/duodenum homeobox protein 1 (PDX1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
