PSENEN
PSENEN,全称为早老素增强子γ-分泌酶亚基(Presenilin enhancer gamma-secretase subunit),别名PEN-2、MDS033。PSENEN是γ-分泌酶复合体的核心组成之一,与早老素(PSEN1/PSEN2)、APH-1等蛋白共同参与跨膜蛋白的切割过程,例如淀粉样前体蛋白(APP)经其剪切后产生β淀粉样蛋白,这类蛋白异常沉积与阿尔茨海默病的病理特征密切相关。PSENEN通过调控Notch受体的活化影响细胞分化与发育,其功能异常可能引发家族性黑蒙痴呆等罕见遗传病。近年来研究发现,PSENEN基因突变还与某些皮肤肿瘤的发生相关。在药物研发领域,针对γ-分泌酶复合体的抑制剂(如Semagacestat)曾进入阿尔茨海默病临床试验,但因干扰Notch通路引发严重副作用而终止。目前研究转向开发选择性调节剂,试图在减少β淀粉样蛋白生成的同时保留Notch信号功能,相关化合物如Nirogacestat已在乳腺癌和硬纤维瘤领域开展II期试验。
热销产品
Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN) (CSB-CF878932HU)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PSENEN Antibody (CSB-PA878932OA01HU)
验证数据

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA878932OA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
PSENEN Antibodies
PSENEN for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA878932OA01HU | PSENEN Antibody | Human | ELISA, IHC |
CSB-PA878932OB01HU | PSENEN Antibody, HRP conjugated | Human | ELISA |
CSB-PA878932OC01HU | PSENEN Antibody, FITC conjugated | Human | |
CSB-PA878932OD01HU | PSENEN Antibody, Biotin conjugated | Human | ELISA |
PSENEN Proteins
PSENEN Proteins for Bos taurus (Bovine)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP688881BO1 CSB-EP688881BO1 CSB-BP688881BO1 CSB-MP688881BO1 CSB-EP688881BO1-B |
Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF688881BO | Recombinant Bovine Gamma-secretase subunit PEN-2 (PSENEN) | in vitro E.coli expression system |
PSENEN Proteins for Dictyostelium discoideum (Slime mold)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP690507DKK1 CSB-EP690507DKK1 CSB-BP690507DKK1 CSB-MP690507DKK1 CSB-EP690507DKK1-B |
Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF690507DKK | Recombinant Dictyostelium discoideum Probable gamma-secretase subunit PEN-2 (psenen) | in vitro E.coli expression system |
PSENEN Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP757686RA1 CSB-EP757686RA1 CSB-BP757686RA1 CSB-MP757686RA1 CSB-EP757686RA1-B |
Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF757686RA | Recombinant Rat Gamma-secretase subunit PEN-2 (Psenen) | in vitro E.coli expression system |
PSENEN Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP812929DIL CSB-EP812929DIL CSB-BP812929DIL CSB-MP812929DIL CSB-EP812929DIL-B |
Recombinant Danio rerio Gamma-secretase subunit PEN-2 (psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PSENEN Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP861450MO1 CSB-EP861450MO1 CSB-BP861450MO1 CSB-MP861450MO1 CSB-EP861450MO1-B |
Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF861450MO | Recombinant Mouse Gamma-secretase subunit PEN-2 (Psenen) | in vitro E.coli expression system |
PSENEN Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP878932HU1 CSB-EP878932HU1 CSB-BP878932HU1 CSB-MP878932HU1 CSB-EP878932HU1-B |
Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF878932HU | Recombinant Human Gamma-secretase subunit PEN-2 (PSENEN) | in vitro E.coli expression system |