RUNX2
RUNX2，即Runt相关转录因子2。别名AML3、CBFA1等。RUNX2是一种关键的转录因子，主要在成骨细胞中表达，对骨骼发育和维持具有重要作用。它通过与DNA上的特定序列结合，调节成骨相关基因的表达，如骨钙蛋白、骨唾液蛋白等，从而促进成骨细胞的分化和骨基质的矿化。RUNX2的功能不仅限于骨骼系统，在肿瘤学中，RUNX2的作用也日益受到关注。它可能参与某些肿瘤的发生和发展，包括骨肉瘤。在肿瘤微环境中，RUNX2可能影响肿瘤细胞的增殖、迁移和侵袭，同时也可能调节肿瘤免疫微环境中免疫细胞的分化和功能，如影响记忆性CD8+ T细胞的发育和组织驻留T细胞的形成。因此，RUNX2在骨骼发育、肿瘤发生以及免疫调节中都扮演着重要角色，是研究骨骼疾病和肿瘤免疫治疗的重要靶点。
热销产品
RUNX2 Antibody (CSB-PA14439A0Rb)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate
All lanes: RUNX2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 56, 55 kDa
Observed band size: 57 kDa
RUNX2 Antibodies
RUNX2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA004038 | RUNX2 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA005568 | RUNX2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA694879 | RUNX2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA059522 | RUNX2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA14439A0Rb | RUNX2 Antibody | Human | ELISA, WB |
| CSB-PA14439B0Rb | RUNX2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA14439C0Rb | RUNX2 Antibody, FITC conjugated | Human | |
| CSB-PA14439D0Rb | RUNX2 Antibody, Biotin conjugated | Human | ELISA |
RUNX2 Proteins
RUNX2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP020594HU CSB-EP020594HU CSB-BP020594HU CSB-MP020594HU CSB-EP020594HU-B |
Recombinant Human Runt-related transcription factor 2 (RUNX2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RUNX2 ELISA Kit
RUNX2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E12935h | Human Core Binding Factor alpha1 CBFA1/RUNX2 ELISA Kit | serum, plasma, tissue homogenates, cell culture supernates | 7.8 pg/mL |
