SEZ6
SEZ6，即癫痫相关同源物6，别名SC-011。它是由位于17q11.2染色体的SEZ6基因编码的蛋白质，属于SEZ6家族中的一员。SEZ6家族包括SEZ6、SEZ6L和SEZ6L2，这些成员在神经系统的发育和功能中起着关键作用。SEZ6的作用机制与其在细胞表面的存在有关，它参与神经树突的形成和神经信号的传递。SEZ6的结构域由5个Sushi结构域和2-3个CUB结构域组成，这些结构域参与蛋白质-蛋白质相互作用，并可能参与细胞间粘附或离子型神经递质受体的调节。此外，SEZ6还可能与补体级联相关，通过促进C3b的因子I裂解和加速C3转化酶的衰变来抑制补体。SEZ6的高表达与肿瘤的发展和转移有关，尤其是在神经内分泌肿瘤中。SEZ6已成为肿瘤治疗的潜在靶点，为开发新的癌症治疗策略提供了重要信息。
热销产品
Recombinant Human Seizure protein 6 homolog (SEZ6), partial (Active) (CSB-MP684467HU2)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 at 2 μg/ml can bind Anti-SEZ6 recombinant antibody (CSB-RA684467MA1HU). The EC50 is 2.324-2.770 ng/mL.
SEZ6 Recombinant Monoclonal Antibody (CSB-RA684467MA1HU)
验证数据
The Binding Activity of Cynomolgus SEZ6 with Anti-SEZ6 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus SEZ6 (CSB-MP6419MOV) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC50 is 0.6865-1.065 ng/mL.
The Binding Activity of Human SEZ6 with Anti-SEZ6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 (CSB-MP684467HU2) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC50 is 2.324-2.770 ng/mL.
SEZ6 Antibodies
SEZ6 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA684467HA01HU | SEZ6 Antibody | Human | ELISA, IF |
| CSB-PA684467HD01HU | SEZ6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA684467HC01HU | SEZ6 Antibody, FITC conjugated | Human |
SEZ6 Proteins
SEZ6 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP684467HU CSB-EP684467HU CSB-BP684467HU CSB-MP684467HU CSB-EP684467HU-B |
Recombinant Human Seizure protein 6 homolog (SEZ6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
