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SLC2A1

SLC2A1全称为葡萄糖转运蛋白1(GLUT1),是人体内分布最广的葡萄糖转运载体,在血脑屏障、红细胞和胎盘等组织中高表达。SLC2A1通过促进葡萄糖跨膜运输维持脑部能量供应,对中枢神经系统功能至关重要。GLUT1缺陷综合征是其最典型的遗传性疾病,患者因转运功能障碍出现婴儿期癫痫、运动障碍和智力发育迟缓,临床通过脑脊液葡萄糖检测结合基因筛查确诊,生酮饮食替代供能是目前主要干预手段。胶质母细胞瘤、乳腺癌等恶性肿瘤中GLUT1常异常高表达,与肿瘤代谢重编程密切相关,这使得SLC2A1成为抗癌药物开发的重要靶点。例如小分子抑制剂BAY-876已在临床前研究中显示出阻断肿瘤葡萄糖摄取的效果。研究人员正探索通过调控GLUT1活性改善糖尿病并发症及阿尔茨海默病能量代谢障碍的新策略。

热销产品

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), partial (CSB-EP021546HU)

验证数据

CSB-EP021546HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC2A1 Recombinant Monoclonal Antibody (CSB-RA297401A0HU)

验证数据

CSB-RA297401A0HU

IHC image of CSB-RA297401A0HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA297401A0HU

IHC image of CSB-RA297401A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

SLC2A1 Antibodies

SLC2A1 for Homo sapiens (Human)

SLC2A1 Proteins

SLC2A1 Proteins for Ovis aries (Sheep)

SLC2A1 Proteins for Homo sapiens (Human)

SLC2A1 Proteins for Oryctolagus cuniculus (Rabbit)

SLC2A1 Proteins for Sus scrofa (Pig)

SLC2A1 Proteins for Mus musculus (Mouse)

SLC2A1 Proteins for Bos taurus (Bovine)

SLC2A1 Proteins for Gallus gallus (Chicken)

SLC2A1 Proteins for Rattus norvegicus (Rat)