TIGIT
TIGIT，即T细胞免疫球蛋白和ITIM结构域蛋白，别名WUCAM、Vstm3、VSIG9。TIGIT由人类TIGIT基因编码，该基因位于3号染色体的q13.33区域。TIGIT是一种抑制性受体，属于Ig超家族，具有细胞外的免疫球蛋白结构域、I型跨膜结构、胞内的免疫受体酪氨酸抑制/激活基序（ITIM/ITAM）。TIGIT的作用机制涉及与CD155等配体的结合，通过胞内ITIM基序传递抑制信号，减少T细胞和NK细胞的激活和增殖，降低细胞因子的产生。TIGIT在调节T细胞和NK细胞的免疫反应中起着重要作用，特别是在肿瘤微环境中，TIGIT的高表达与免疫抑制和肿瘤逃逸相关。TIGIT阻断剂在不同肿瘤模型中显示出治疗潜力，是癌症治疗的新靶点。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
FACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.
The purity of Human TIGIT was greater than 95% as determined by SEC-HPLC
TIGIT Antibody (CSB-PA675446LA01HU)
验证数据
Immunofluorescent analysis of HepG2 cells using CSB-PA675446LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
TIGIT Antibodies
TIGIT for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA675446LA01HU | TIGIT Antibody | Human | ELISA, IF |
| CSB-PA675446LB01HU | TIGIT Antibody, HRP conjugated | Human | ELISA |
| CSB-PA675446LC01HU | TIGIT Antibody, FITC conjugated | Human | |
| CSB-PA675446LD01HU | TIGIT Antibody, Biotin conjugated | Human | ELISA |
TIGIT Proteins
TIGIT Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023545MO1 CSB-EP023545MO1 CSB-BP023545MO1 CSB-MP023545MO1 CSB-EP023545MO1-B |
Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains (Tigit), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023545MO | Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains (Tigit) | in vitro E.coli expression system |
TIGIT Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP675446HU CSB-BP675446HU CSB-EP675446HU-B |
Recombinant Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP675446HU | Recombinant Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT), partial | E.coli |
| CSB-MP675446HU | Recombinant Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT), partial (Active) | Mammalian cell |
| CSB-MP675446HUf3 | Recombinant Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT), partial | Mammalian cell |
