TNFSF15
TNFSF15,也称为血管内皮生长抑制因子(VEGI)或TL1A,是由TNFSF15基因编码的蛋白质,位于染色体9q32上。该蛋白质由251个氨基酸组成,包含胞质结构域、跨膜域和胞外结构域,并能形成稳定的同源三聚体结构。TNFSF15主要作为死亡受体3(DR3)的配体,参与调控VEGF/VEGFR信号通路,影响内皮细胞的增殖、凋亡以及淋巴管生成等过程。它在血管生成、淋巴管形成、免疫调节等多个方面发挥重要作用,并为涉及血管通透性增加的病理过程(如肿瘤、脑卒中等)的治疗提供了新的靶点。
更多相关阅读:TNFSF15/TL1A:药企巨头抢滩布局,下一个百亿级靶点的崛起之路
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验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml on streptavidin coated plates can bind Anti-TNFSF15 antibody (CSB-RA023992MA1HU). The EC50 is 0.2732 - 0.6370 ng/mL.
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU) at 2 μg/ml can bind Biotinylated Macaca mulatta TNFSF15. The EC50 is 0.2589-0.3025 ng/mL.
TNFSF15 Recombinant Monoclonal Antibody (CSB-RA023992MA1HU)
验证数据

The Binding Activity of Biotinylated Macaca mulatta TNFSF15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-TNFSF15 recombinant antibody at 2 μg/mL can bind Biotinylated Macaca mulatta TNFSF15 (CSB-MP5305MOW-B). The EC50 is 0.2589-0.3025 ng/mL.

The Binding Activity of Biotinylated TNFSF15 with Anti-TNFSF15 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Biotinylated Human TNFSF15 at 2 μg/mL on streptavidin coated plates can bind Anti-TNFSF15 recombinant antibody (CSB-RA023992MA1HU). The EC50 is 0.2732 - 0.6370 ng/mL.

The Binding Activity of Mouse Tnfsf15 with Anti-TNFSF15 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Tnfsf15 (CSB-MP729268MO) at 2 μg/mL can bind Anti-TNFSF15 recombinant antibody. The EC50 is 1.671-2.506 ng/mL.
TNFSF15 Antibodies
TNFSF15 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA983205 | TNFSF15 Antibody | Human | ELISA,WB,IF |
CSB-PA004447 | TNFSF15 Antibody | Human | WB, IF, ELISA |
CSB-PA577745 | TNFSF15 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA065340 | TNFSF15 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA023992ESR1HU | TNFSF15 Antibody | Human, Mouse | ELISA, WB |
CSB-PA023992ESR2HU | TNFSF15 Antibody | Human | ELISA, IHC |
CSB-RA023992MA1HU | TNFSF15 Recombinant Monoclonal Antibody | Human, Cynomolgus, Mouse | ELISA |
TNFSF15 Proteins
TNFSF15 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP023992HU1 CSB-EP023992HU1 CSB-BP023992HU1 CSB-MP023992HU1 CSB-EP023992HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP002341HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active) | E.Coli |
CSB-CF023992HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15) | in vitro E.coli expression system |
CSB-AP004991HU | Recombinant Human Tumor necrosis factor ligand superfamily member 15 (TNFSF15) (Active) | E.coli |
CSB-MP023992HU(F2) | Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15) (Active) | Mammalian cell |
CSB-MP023992HU1-B | Recombinant Human Tumor necrosis factor ligand superfamily member 15(TNFSF15),partial,Biotinylated (Active) | Mammalian cell |
TNFSF15 ELISA Kit
TNFSF15 ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E15770h | Human tumor necrosis factor superfamily 15 (TL1A/TNFSF15) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.195 ng/mL |